We checked up the file RUNFILE64.EXE and found it hazardous.
The file RUNFILE64.EXE must be deleted from the system immediately.
Kill the process RUNFILE64.EXE and remove RUNFILE64.EXE from the Windows startup.

RUNFILE64.EXE Information and Removal:
MD5 of RUNFILE64.EXE = C373639CC70FA7F87ABC301E6F3CF991
RUNFILE64.EXE size is 6933937 bytes.
Full path on a computer: %SYSTEM%\RUNFILE64.EXE
Related Files:
%COMMONPROGRAMS%\SENUKE\MANUAL.LNK
%COMMONPROGRAMS%\SENUKE\SENUKE.LNK
%COMMONPROGRAMS%\SENUKE\UNINSTALL SENUKE.LNK
%DESKTOPDIR%\SENUKE.LNK
%SYSTEM%\SERSICES.EXE
%TEMP%\IS-3U1T3.TMP\RUNFILE64.TMP
%TEMP%\IS-LHM1T.TMP\_ISETUP\_REGDLL.TMP
%TEMP%\IS-LHM1T.TMP\_ISETUP\_SHFOLDR.DLL
%TEMP%\MUST READ.TXT
%TEMP%\SEMARANG.DAT
%SYSTEM%\RUNFILE64.EXE
%TEMP%\SETUP2.EXE
%PROGRAMFILES%\SENUKE\BATCHRESEARCHCOMPLETE.WAV
%PROGRAMFILES%\SENUKE\CLOSE_MSGBOXES.EXE
%PROGRAMFILES%\SENUKE\COMPLETE.WAV
%PROGRAMFILES%\SENUKE\EMAILVCOMPLETE.WAV
%PROGRAMFILES%\SENUKE\MANUAL.PDF
%PROGRAMFILES%\SENUKE\PINGINGCOMPLETE.WAV
%PROGRAMFILES%\SENUKE\REGCONTROLS.BAT
%PROGRAMFILES%\SENUKE\SENUKE.EXE
%PROGRAMFILES%\SENUKE\SENUKE.EXE.MANIFEST
%PROGRAMFILES%\SENUKE\UNINS000.DAT
%PROGRAMFILES%\SENUKE\UNINS002.EXE
%PROGRAMFILES%\SENUKE\UNINS002.DAT
%WINDIR%\IS-I0S5R.EXE
%WINDIR%\IS-I0S5R.LST
%WINDIR%\IS-I0S5R.MSG
%SYSTEM%\CHILKATCHARSET.DLL
%SYSTEM%\CHILKATFTP2.DLL
%SYSTEM%\CHILKATHTTP.DLL
%SYSTEM%\CHILKATMAIL_V7_9.DLL
%SYSTEM%\CHILKATSOCKET.DLL
%SYSTEM%\CHILKATUPLOAD.DLL
%SYSTEM%\CHILKATXML.DLL
%SYSTEM%\CKSTRING.DLL
%SYSTEM%\IJL11.DLL
%SYSTEM%\IS-D4SBD.TMP
%SYSTEM%\MSWORD.OLB
%SYSTEM%\SEMARANG.DAT
%SYSTEM%\VB6STKIT.DLL